Related Experiment Videos
Effect of POMC-derived peptides on corticosterone secretion during the stress hypo-responsive period in rat
C Oliver1, F Boudouresque, O Lacroix
1Laboratoire de Neuroendocrinologie Expérimentale, INSERM U 297, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Marseille, France.
Abstract:
During the stress hyporesponsive period (postnatal days 2-10), the stimulation of corticosterone secretion by ACTH is very low. In our study, we have observed that administration of ACTH during 3 consecutive days is followed by a striking increase in corticosterone response to an acute ACTH test. A comparable potentiation of corticosterone secretion was observed after a similar treatment with Lys gamma 3-MSH. The 3 day-treatment with each peptide induced an increase in adrenal weight. Similar data were obtained with alpha-MSH. However, corticosterone response to ACTH was not significantly altered following the same pattern of alpha-MSH administration.