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Updated: Aug 12, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
[Genetics of colorectal cancer. Practical value]
1Laboratoire de génétique des tumeurs, institut Curie, Paris, France.
Abstract:
The age and family history of colorectal cancer are the main risk factors for colorectal cancer. Taking into account the family history of colorectal cancer, the first degree relatives of a patient have a risk that increases to 2 or 3 as compared to general population. The genetic basis for colorectal cancer was recently investigated by complex segregation analysis. They favoured a dominant gene with a gene frequency of 6 :1000. These analyses represent the first step in order to localize the susceptibility genes that are responsible for the familial aggregation of colorectal cancer.
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