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Pharmaco-informatics: more precise drug therapy from "multiple model" (MM) stochastic adaptive control regimens:
R W Jelliffe1, D Bayard, A Schumitzky
1Laboratory of Applied Pharmacokinetics, University of Southern California School of Medicine, Los Angeles 90033.
Proceedings. Symposium on Computer Applications in Medical Care
|January 1, 1994
Abstract:
MM stochastic control of dosage regimens permits essentially full use of information, either in a population pharmacokinetic model or a Bayesian updated MM parameter set, to achieve and maintain selected therapeutic goals with optimal precision. The regimens are visibly more precise than those developed using mean parameter values. Bayesian MM feedback has now also been implemented.