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Changes in creatine kinase expression induced by exercise in borderline hypertensive rat hearts
A L Golden1, J M Bright, J E Lawler
1Intercollegiate Physiology Program, University of Tennessee, Knoxville.
Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|September 1, 1994
Summary
Exercise training in borderline hypertensive rats induced cardiac changes, including increased creatine kinase (CK) expression, similar to those seen in hypertensive hearts. This suggests exercise can mimic hypertensive cardiac remodeling in susceptible individuals.
Area of Science:
- Cardiology
- Exercise Physiology
- Biochemistry
Background:
- Cardiac hypertrophy in hypertensive hearts increases morbidity and mortality.
- This remodeling differs from exercise-induced cardiac adaptations.
- Creatine kinase (CK) isozymes (BB and MB) are markers of cardiac stress.
Purpose of the Study:
- To investigate if exercise training induces myocardial expression of CK-BB and CK-MB in normotensive and borderline hypertensive rats.
- To compare exercise-induced CK changes with those in hypertensive hypertrophy.
Main Methods:
- Spontaneously hypertensive (SHR), borderline hypertensive (BHR), and Wistar-Kyoto (WKY) rats were used.
- Groups were subjected to a high-salt diet or swim training for hypertrophy induction.
- Myocardial expression of CK-BB and CK-MB was analyzed.
Main Results:
- In SHR, both high-salt diet and swim training increased CK-BB and CK-MB expression.
- Exercise effects were confounded by exacerbated hypertension in SHR.
- In BHR, swim training (10 months) induced mild hypertrophy, decreased heart rate, and increased CK-BB/CK-MB expression.
- No significant CK changes were observed in WKY rats or in BHR on a high-salt diet.
Conclusions:
- Exercise-induced cardiac training effects in BHR led to CK isozyme expression changes similar to hypertensive hearts.
- These findings highlight potential similarities in cardiac remodeling between exercise and hypertension in susceptible models.