Pharmacokinetics and distribution of thiamphenicol in sheep given repeated intramuscular doses

The pharmacokinetics of thiamphenicol and its distribution in various body fluids were studied after repeated intramuscular injection in clinically healthy adult Moroccan crossed Sardi-D'Man sheep. Thiamphenicol was rapidly absorbed from injection sites yielding peak plasma concentrations within 15-30 min. The elimination from the blood was also rapid, with a biological half-life of 1.51 +/- 0.51 h. The distribution pattern of thiamphenicol revealed that this antibiotic can penetrate many remote sites of the body. With the exception of the cerebrospinal fluid, concentrations of the drug in other body fluids were higher than the corresponding plasma concentrations.