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Plasma polymorphonuclear elastase in patients with hyperthyroidism

H Hara1, Y Ban

  • 13rd Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Endocrine Journal
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

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Plasma polymorphonuclear elastase (PMNE) levels are elevated in hyperthyroidism, particularly Graves' disease. Methimazole treatment normalized PMNE levels, indicating its utility in assessing thyroid function.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Biochemistry

Background:

  • Hyperthyroidism is associated with elevated inflammatory markers.
  • Polymorphonuclear elastase (PMNE) is a neutrophil-derived protease implicated in inflammatory processes.

Purpose of the Study:

  • To investigate plasma PMNE levels in hyperthyroid patients.
  • To evaluate the effect of methimazole treatment on PMNE levels.
  • To explore the correlation between PMNE and thyroid function markers.

Main Methods:

  • Plasma PMNE levels were measured in hyperthyroid patients (including Graves' disease) before and during methimazole treatment.
  • Levels were compared to normal subjects and patients with thyroid adenoma.
  • Correlations with serum free triiodothyronine (FT3) and TSH receptor antibodies (TRAb) were analyzed.

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Main Results:

  • Plasma PMNE levels were significantly higher in hyperthyroid patients compared to controls.
  • Methimazole treatment led to a significant reduction in PMNE levels in Graves' disease patients with normalized thyroid function.
  • A positive correlation was observed between plasma PMNE and serum FT3, but not with serum TRAb.

Conclusions:

  • Elevated plasma PMNE in hyperthyroidism, especially Graves' disease, suggests neutrophil activation.
  • Decreased PMNE levels following successful methimazole treatment indicate its potential as a biomarker for peripheral thyroid function.
  • PMNE may be secreted by neutrophils in the hyperthyroid state, reflecting disease activity.