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Related Experiment Videos

[Side effects of third generation progestins]

R Sitruk-Ware1

  • 1Medical Department, Ciba-Ceigy Ltd, Basle, Switzerland.

Contraception, Fertilite, Sexualite (1992)
|April 1, 1993
PubMed
Summary

Newer oral contraceptives (OCs) utilize third-generation progestins to minimize adverse drug reactions (ADRs) and cardiovascular risks. These advanced formulations aim for improved safety and efficacy in women.

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Reproductive Health

Context:

  • Oral contraceptives (OCs) are widely used for birth control.
  • Adverse drug reactions (ADRs) are a significant concern for OCs.
  • Efficacy and side effects are linked to steroid dose, estrogen-progestin balance, and molecular properties.

Purpose:

  • To review the evolution of OCs, focusing on reducing adverse drug reactions (ADRs).
  • To discuss the role of progestins in cardiovascular risk and lipid profile changes.
  • To introduce third-generation progestins designed to minimize androgenic properties and improve safety.

Summary:

  • Cardiovascular risks in OC users were initially linked to ethinylestradiol (EE), leading to dose reductions.
  • Later, progestins with androgenic properties were implicated in cardiovascular events and adverse lipid changes.
  • Newer third-generation progestins, derived from levonorgestrel, show reduced androgenicity and do not oppose beneficial estrogenic effects on SHBG and HDL.

Impact:

  • Development of safer oral contraceptives with fewer side effects.
  • Potential for improved cardiovascular health and lipid profiles in women using OCs.
  • Advancement in contraceptive technology through novel progestin development.

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