[Use of purified FSH in female infertility]

The use of purified FSH versus classical hMG for normo-ovulatory women superovulation in an IVF programme could reduce the spontaneous LH surges incidence and/or increase the numbers of retrieved oocytes and transfers. In poor responders the advantage of high FSH doses is very discussed. Because of possible adverse effects of LH excess, high responders remain theoretically the best indication. Nevertheless only few prospective studies showed a significant reduction of multiple pregnancies and hyperstimulations by pure FSH. Most effective seems to be using low gonadotropins doses.