Related Experiment Video

Updated: Jul 27, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

[The experimental coronavirus infection of monkeys]

E I Goncharuk, Z V Shevtsova, R I Krylova

    Mikrobiolohichnyi Zhurnal (Kiev, Ukraine : 1993)
    |May 1, 1994
    PubMed

    Insights

    Researchers successfully reproduced coronavirus (CV) infection in rhesus monkeys for the first time. This new animal model exhibits chronic disease with relapses, aiding human CV infection research.

    Area of Science:

    • Veterinary Virology
    • Primate Models
    • Infectious Disease Research

    Context:

    • First successful reproduction of coronavirus (CV) infection in non-human primates (Macaca mulatta).
    • Utilized a novel CV strain (CVRM 281) isolated from a naturally infected rhesus monkey.
    • Established a chronic infection model with periodical relapses and demonstrated virus persistence.

    Purpose:

    • To establish a non-human primate model for studying coronavirus infections.
    • To investigate the pathogenesis and clinical course of CV infection in a susceptible animal model.
    • To provide a platform for evaluating potential therapeutics and vaccines.

    Summary:

    • Experimental CV infection in rhesus monkeys resulted in a chronic disease course.
    • Key pathological findings include enterocolitis and pneumonia with characteristic histological lesions.
    • The model replicates key features of CV infection, including relapses and viral persistence.

    Impact:

    • Provides a valuable animal model for understanding human coronavirus infections.
    • Facilitates research into obscure aspects of CV pathogenesis and disease progression.
    • Enables preclinical testing of antiviral strategies and vaccine efficacy in a relevant host.

    More Related Videos

    Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images08:52

    Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

    Published on: May 23, 2019

    Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

    Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

    Published on: November 5, 2021

    Related Concept Videos

    Viral Recombination00:57

    Viral Recombination

    Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
    Coronavirus01:29

    Coronavirus

    Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...