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Related Experiment Videos

Cytokine binding to CD4+ inflammatory cells: implications for asthma

D M Center1, H Kornfeld, M J Wu

  • 1Pulmonary Center, Boston University School of Medicine, Massachusetts 02118.

American Journal of Respiratory and Critical Care Medicine
|November 1, 1994
PubMed
Summary

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Lung chemokine factor (LCF) may play an early role in asthma by attracting CD4+ T cells, monocytes, and eosinophils. Histamine may trigger LCF secretion, contributing to airway inflammation.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Cell Biology

Background:

  • Asthma involves airway inflammation with increased CD4+ T cells, monocytes, and eosinophils.
  • Previous research focused on CD4+ T cell-derived cytokines (e.g., IL-4, IL-5) in asthma.
  • The role of other T cell secreted proteins, like lung chemokine factor (LCF), in early asthma pathogenesis is less understood.

Purpose of the Study:

  • To investigate the hypothesis that T cell secreted proteins, specifically LCF, contribute to early airway inflammation in asthma.
  • To explore the potential role of histamine in stimulating LCF production by T cells.
  • To identify mechanisms by which mast cell mediators influence chemotactic lymphokine secretion.

Main Methods:

  • Focus on early events in antigen-induced asthma.

Related Experiment Videos

  • Investigate mechanisms of CD4+ T cell, eosinophil, and monocyte accumulation.
  • Utilize CD4 as a chemotactic factor receptor to study LCF secretion.

    • Main Results:

    • LCF is present in bronchoalveolar lavage (BAL) early after antigen challenge.
    • LCF exhibits chemotactic effects on CD4+ T cells, monocytes, and eosinophils.
    • LCF also activates monocytes and CD4+ T cells.
    • T cells producing LCF show unusual responsiveness to histamine.

    Conclusions:

    • LCF is an early mediator in antigen-induced airway inflammation.
    • Histamine may play a role in LCF secretion, contributing to CD4+ T cell recruitment.
    • Further research is needed to fully elucidate LCF's role in asthma pathogenesis.