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Related Experiment Videos

Inflammation in nocturnal asthma?

D S Postma1, Y Oosterhoff, W M van Aalderen

  • 1Department of Pulmonology, Allergy, and Pediatric Pulmonology University Hospital, Groningen, The Netherlands.

American Journal of Respiratory and Critical Care Medicine
|November 1, 1994
PubMed
Summary
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Nocturnal asthma symptoms indicate more severe asthma, not a distinct condition. Research suggests changing the term to "asthma with nocturnal symptoms" for clarity.

Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology
  • Sleep Medicine

Background:

  • Nocturnal asthma is characterized by nighttime asthma exacerbations.
  • Indirect evidence suggests increased nocturnal inflammation, including elevated eosinophils and histamine levels.
  • However, studies also indicate nocturnal asthma may reflect overall asthma severity.

Purpose of the Study:

  • To investigate the underlying mechanisms and characteristics of nocturnal asthma.
  • To determine if nocturnal asthma represents a unique pathophysiological entity or a marker of severe asthma.
  • To propose a more accurate terminology for nocturnal asthma.

Main Methods:

  • Review and synthesis of existing studies on nocturnal asthma.
  • Analysis of circulating inflammatory markers (e.g., eosinophils, histamine).

Related Experiment Videos

  • Assessment of airway hyperresponsiveness (AHR) using methacholine and other agents.
  • Examination of bronchoalveolar lavage (BAL) fluid for inflammatory mediators.

    • Main Results:

    • Patients with nocturnal asthma exhibit higher circulating eosinophil counts and elevated PGD2 levels compared to those without.
    • Airway hyperresponsiveness measures are generally lower in patients experiencing nocturnal asthma.
    • BAL fluid analysis did not consistently show increased inflammation specific to nighttime in nocturnal asthma patients.
    • Histamine and eosinophil activation markers show some nocturnal increases but are also elevated in general asthma severity.

    Conclusions:

    • Nocturnal asthma symptoms are likely an indicator of more severe underlying asthma rather than a separate disease entity.
    • The term "nocturnal asthma" may be misleading.
    • The study suggests renaming it to "asthma with nocturnal symptoms" to better reflect its nature as a manifestation of asthma severity.