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Lipoprotein metabolism and thrombosis
1Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College of St Bartholomew's Hospital, London, UK.
Current Opinion in Lipidology
|June 1, 1994
Summary
Long-chain saturated fatty acids activate blood coagulation factor VII. This may promote thrombin generation and inflammation in atherosclerosis, especially with tissue factor presence.
Area of Science:
- Biochemistry
- Hematology
- Cardiovascular Science
Background:
- Triglyceride-rich lipoproteins (TRLs) lipolysis yields long-chain saturated fatty acids like stearic acid.
- These fatty acids may activate the contact system of coagulation and factor VII.
- Elevated factor VII activity is linked to prothrombotic states.
Purpose of the Study:
- To explore the role of long-chain saturated fatty acids in coagulation activation.
- To investigate the implications of activated factor VII in atherothrombosis.
Main Methods:
- Analysis of TRL lipolysis products.
- Assessment of coagulation factor activation.
- Modeling of thrombin generation in proatherosclerotic conditions.
Main Results:
- Stearic acid from TRL lipolysis activates the contact system and factor VII.
- Increased activated factor VII accelerates thrombin generation, particularly with tissue factor.
- Thrombin promotes inflammation and proliferation in atheroma.
Conclusions:
- Long-chain saturated fatty acids contribute to a prothrombotic state via factor VII activation.
- This mechanism may exacerbate atheroma development and vascular injury.
- Targeting this pathway could offer therapeutic strategies for cardiovascular disease.