Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acrocentric chromosome associations in man

P A Jacobs, M Mayer, N E Morton

    American Journal of Human Genetics
    |November 1, 1976
    PubMed
    Summary

    Chromosome association varies significantly between individuals, with each chromosome pair having a unique association probability. Associations appear random, not preferential, and are not linked to chromosome phenotype.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Possible founder effect of rapsyn N88K mutation and identification of novel rapsyn mutations in congenital myasthenic syndromes.

    Journal of medical genetics·2003
    Same author

    Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension.

    Blood pressure·2003
    Same author

    Clinical neurokinesiology of spastic gait.

    Bratislavske lekarske listy·2002
    Same author

    Treatment of cluster headache with topiramate: effects and side-effects in five patients.

    Cephalalgia : an international journal of headache·2002
    Same author

    Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase.

    Reproduction (Cambridge, England)·2002
    Same author

    Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells.

    Pflugers Archiv : European journal of physiology·2002

    Area of Science:

    • Cytogenetics
    • Molecular Biology
    • Genetics

    Background:

    • Satellite DNA associations are crucial for chromosome stability and function.
    • Previous studies suggested preferential associations between specific chromosomes.

    Purpose of the Study:

    • To investigate the sources of variation in chromosome association proportions.
    • To develop and test a mathematical model for pairwise satellite association.
    • To determine if chromosome phenotype influences association probability.

    Main Methods:

    • Statistical analysis of chromosome association data.
    • Development of a mathematical theory for pairwise satellite association.
    • Observation of banded chromosomes.

    Main Results:

    • Chromosome heterogeneity was a significant source of variation in association proportions.
    • Culture, slide, and observer were negligible sources of variation for association proportions.
    • No significant evidence for preferential association between specific chromosomes was found.
    • A mathematical theory for pairwise satellite association accurately fit observed data.
    • No correlation was found between chromosome phenotype and association probability.

    Conclusions:

    • Individual variation in chromosome association is substantial.
    • Chromosome associations appear to be random rather than preferential.
    • The developed mathematical model provides a framework for understanding satellite association.

    Related Experiment Videos