Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Are agents affecting platelet functions clinically useful?

M Verstraete

    The American Journal of Medicine
    |December 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Influencing factors in knee kinematics following posteriorly stabilized knee arthroplasty: a comprehensive analysis.

    Acta orthopaedica Belgica·2025
    Same author

    Trends For Smaller Medical Journals.

    Acta clinica Belgica·2016
    Same author

    Temperature dependence of the electronic structure of semiconductors and insulators.

    The Journal of chemical physics·2015
    Same author

    Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.

    British journal of cancer·2015
    Same author

    [Update on the management of acute viral bronchiolitis: proposed guidelines of Grand Ouest University Hospitals].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2013
    Same author

    [Management of bronchiolitis in general practice and determinants of treatment being discordant with guidelines of the HAS].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2013

    Few drugs effectively prevent thrombosis. Aspirin and dipyridamole combinations show promise for myocardial infarction and general surgery, while sulfinpyrazone is effective for cerebrovascular disease and prosthetic heart valves.

    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine
    • Nephrology

    Background:

    • Limited clinical recommendations exist for antiplatelet drugs in thrombosis prevention despite numerous trials.
    • Current evidence for aspirin and other platelet function inhibitors in peripheral arterial occlusion and vascular grafting is insufficient.

    Purpose of the Study:

    • To review the current evidence for drugs affecting platelet function in the prevention of arterial and venous thrombosis.
    • To identify areas where firm clinical recommendations can be made and where further research is needed.

    Main Methods:

    • Systematic review of clinical trials on antiplatelet drugs.
    • Analysis of drug efficacy in various conditions including cerebrovascular disease, myocardial infarction, prosthetic heart valves, glomerulonephritis, transplantation, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and deep vein thrombosis.

    Related Experiment Videos

    Main Results:

    • Sulfinpyrazone shows effectiveness in cerebrovascular disease and for prosthetic heart valves, normalizing platelet survival and correlating with reduced thromboembolism.
    • Aspirin and dipyridamole combination therapy demonstrated reduced morbidity and mortality in myocardial infarction prevention and comparable protection to low-dose heparin in general surgery.
    • Dextran 70 showed the most convincing reduction in deep vein thrombosis in orthopedic surgery, though aspirin and dipyridamole efficacy requires further confirmation.

    Conclusions:

    • Antiplatelet drugs, particularly combinations like aspirin and dipyridamole, show potential in specific thrombotic conditions, including myocardial infarction and general surgery prophylaxis.
    • Further trials are needed to confirm the efficacy of various antiplatelet agents in cerebrovascular disease, prosthetic heart valves, and post-transplant scenarios.
    • The effectiveness of antiplatelet drugs in peripheral arterial disease, glomerulonephritis, and specific hematologic disorders remains largely unproven.