Changes in calcium currents during ethanol withdrawal in a genetic mouse model
Related Experiment Video
Updated: Apr 11, 2026
Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
J L Perez-Velazquez1, T A Valiante, P L Carlen
1Playfair Neuroscience Unit, Toronto Hospital Research Institute, Bloorview Epilepsy Program, University of Toronto, Ont., Canada.
Abstract:
Changes in voltage dependent calcium currents in the dentate gyrus of the hippocampal slice during ethanol withdrawal were studied using an alcohol withdrawal seizure prone mouse strain (WSP) and compared to a withdrawal-resistant strain (WSR). There was a significant increase in the high voltage activated calcium currents during the withdrawal period in the WSP strain, while those of the resistant strain showed no significant enhancement. These results suggest that an increase in calcium currents is one factor involved in the alcohol withdrawal hyperexcitability of the prone strain observed in vivo.
