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"Normothermic range" temperature affects myocardial infarct size

G L Chien1, R A Wolff, R F Davis

  • 1Department of Anesthesiology, Oregon Health Sciences University, Portland.

Cardiovascular Research
|July 1, 1994
PubMed
Summary
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Mild temperature increases above hypothermia significantly increase myocardial infarct size in rabbits. This effect on infarct size is independent of heart rate changes during acute coronary occlusion-reperfusion.

Area of Science:

  • Cardiovascular Research
  • Myocardial Infarction Studies
  • Thermoregulation in Physiology

Background:

  • Myocardial infarct size is a critical determinant of heart function post-ischemia.
  • The role of mild temperature variations above hypothermia in modulating infarct size remains incompletely understood.
  • Acute coronary occlusion-reperfusion models are crucial for studying myocardial injury.

Purpose of the Study:

  • To investigate the impact of small temperature increases above hypothermia on myocardial infarct size.
  • To determine if the relationship between temperature and infarct size is independent of heart rate variations.

Main Methods:

  • Open-chest rabbits underwent 30-minute coronary artery occlusion followed by 3-hour reperfusion.
  • Blood temperatures were modulated between 35-42°C using surface methods.

Related Experiment Videos

  • Two groups were studied: one with natural heart rate variation (NP) and another with a constant heart rate (P).
  • Infarct size was quantified using the tetrazolium method.

    • Main Results:

    • Temperature was precisely controlled (±0.25°C) throughout the experiment.
    • Area at risk for infarction did not significantly differ across temperatures.
    • A significant positive correlation was observed between temperature and normalized infarct size in both non-paced (NP) and paced (P) groups.
    • The correlation between infarct size and temperature was statistically similar between groups, indicating independence from heart rate.

    Conclusions:

    • Temperatures within the 35-42°C range significantly influence myocardial infarct size.
    • The observed effect of temperature on infarct size is independent of concurrent heart rate changes.