Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiopulmonary bypass, temperature, and central nervous system dysfunction

R F McLean1, B I Wong, C D Naylor

  • 1Department of Anaesthesia, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.

Circulation
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reef islands have continually adjusted to environmental change over the past two millennia.

Nature communications·2023
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Comparison of elicitor-based effects on metabolic responses of Taxus × media hairy roots in perfluorodecalin-supported two-phase culture system.

Plant cell reports·2018
Same author

Influence on jitter measurement of components from distant fibres in potential recorded by single-fibre electrode.

Acta physiologica (Oxford, England)·2017
Same author

The Role of Elements in Anxiety.

Vitamins and hormones·2017
Same author

Major conservation policy issues for biodiversity in Oceania.

Conservation biology : the journal of the Society for Conservation Biology·2009

This study found that while psychomotor speed declined after cardiac surgery, memory remained unaffected regardless of cardiopulmonary bypass temperature. Moderate hypothermia did not show a neuroprotective effect in this patient group.

Area of Science:

  • Cardiovascular Surgery
  • Neurology
  • Anesthesiology

Background:

  • Neurological injury is a significant complication following cardiac surgery.
  • The role of hypothermic cardiopulmonary bypass (CPB) in neuroprotection is debated with the rise of warm heart surgery.
  • Previous research suggested normothermic CPB may not increase neurological risk.

Purpose of the Study:

  • To compare neurological and neuropsychological dysfunction incidence in patients undergoing normothermic versus hypothermic cardiopulmonary bypass during aortocoronary bypass surgery.
  • To evaluate the neuroprotective potential of moderate hypothermia in cardiac surgery patients.

Main Methods:

  • A randomized trial involving 201 aortocoronary bypass patients allocated to normothermic or moderate hypothermic CPB.

Related Experiment Videos

  • Neurological and neuropsychological evaluations were conducted preoperatively, 5 days post-operation, and at 3-month follow-up.
  • A comprehensive neuropsychological test battery assessed memory, psychomotor speed, and coordination, with examiners blinded to CPB temperature.

    • Main Results:

    • 155 patients completed the study; 153 underwent full neuropsychological testing.
    • Early postoperative decline in psychomotor speed and coordination was observed, resolving by 3 months.
    • No significant difference in neurological deficits or memory function was found between normothermic and hypothermic CPB groups.
    • One perioperative stroke occurred in the normothermic group, and another patient in the same group could not complete testing due to stroke.

    Conclusions:

    • Normothermic versus hypothermic cardiopulmonary bypass did not result in differences in neurological or neuropsychological outcomes.
    • A transient decline in psychomotor speed was noted post-surgery, independent of CPB temperature.
    • Moderate hypothermia did not demonstrate a neuroprotective benefit in this cohort undergoing aortocoronary bypass surgery.