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Cell death in the developing olfactory epithelium of rat embryos
1Laboratoire de Physiologie Neurosensorielle, Université Claude Bernard/Lyon I, Villeurbanne, France.
Brain Research. Developmental Brain Research
|June 17, 1994
Summary
Massive cell death occurs in developing rat olfactory epithelium, with apoptosis and non-lysosomal disintegration observed early on. This wave of cell death is crucial for olfactory system development.
Area of Science:
- Developmental Biology
- Cell Biology
- Neuroscience
Background:
- The developing olfactory epithelium is critical for sensory perception.
- Understanding cell death mechanisms is key to developmental processes.
Purpose of the Study:
- To investigate the cell death processes during olfactory epithelium development in rat embryos.
- To characterize the types of cell death occurring and their timing.
Main Methods:
- Light and electron microscopy were used.
- Rat embryos from embryonic days 12-18 were examined.
Main Results:
- A massive wave of cell death was observed at embryonic days 12-13.
- Two coexisting cell death types were identified: apoptosis and non-lysosomal disintegration.
- Apoptotic figures were occasionally observed from embryonic day 14 onwards.
Conclusions:
- The early massive cell death wave, involving distinct mechanisms, plays a significant role in olfactory system morphogenesis.
- This study elucidates critical cellular events shaping the developing olfactory system.
