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Updated: Jul 26, 2026
11:46
Single Molecule Analysis of Laser Localized Psoralen Adducts
Published on: April 20, 2017
Multiple lentigines confined to psoriatic plaques
N P Burrows1, S Handfield-Jones, B E Monk
1Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK.
Clinical and Experimental Dermatology
|September 1, 1994
Summary
Psoriasis treatment can cause dark spots on the skin. These naevus spilus-like hyperpigmentation and lentigines can occur even without PUVA therapy, suggesting other factors may be involved.
Area of Science:
- Dermatology
- Cutaneous Biology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Previous reports linked naevus spilus-like hyperpigmentation to resolving psoriasis plaques, often associated with PUVA therapy.
Observation:
- A case of oral PUVA (psoralen plus ultraviolet A light) leading to lentigines on resolving psoriasis sites is presented.
- Similar pigmentation patterns were observed in two patients who had not undergone PUVA therapy.
Findings:
- The development of naevus spilus-like hyperpigmentation and lentigines at sites of resolving psoriasis is not solely dependent on PUVA therapy.
- This suggests that the resolution of psoriatic plaques itself may trigger these pigmentary changes.
Implications:
- PUVA therapy is not a prerequisite for developing this unusual post-psoriatic pigmentation.
- Further research is needed to elucidate the underlying mechanisms of pigmentation changes in resolving psoriasis.
