Asymmetrical osteoarthritis in a patient with Ehlers-Danlos syndrome and poliomyelitis

The case is reported of a 71 year old man diagnosed as having Type I Ehlers-Danlos syndrome, a condition associated with the premature development of osteoarthritis, who contracted poliomyelitis as a young man as a result of which he has developed asymmetrical osteoarthritis involving the limbs unaffected by the poliomyelitis. This observation lends further support to the hypothesis that an intact neural pathway may be necessary for the development of arthritis.