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Infection caused by Propionibacterium in children
1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC.
Clinical Pediatrics
|August 1, 1994
Summary
Propionibacterium species, primarily Propionibacterium acnes, can cause serious infections in children, including bacteremia and abscesses. Early diagnosis and treatment are crucial for better outcomes in these pediatric cases.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Microbiology
- Anaerobic Bacteriology
Background:
- Propionibacterium species are part of the normal human flora.
- Their role as pediatric pathogens is often underestimated.
- This study reviews a significant case series over 15 years.
Purpose of the Study:
- To identify and characterize Propionibacterium infections in children.
- To determine the clinical significance and spectrum of these infections.
- To analyze predisposing factors and treatment outcomes.
Main Methods:
- Retrospective analysis of 2,003 clinical specimens over 15 years.
- Identification of anaerobic bacteria, focusing on Propionibacterium isolates.
- Clinical data review for infection types, patient conditions, and treatments.
Main Results:
- 386 Propionibacterium isolates were recovered; 343 (89%) were Propionibacterium acnes.
- 50 isolates (13%) from 45 patients caused clinically significant infections.
- Common infections included bacteremia, ear infections, abscesses, and CNS infections. Underlying conditions were present in 73% of infected children.
Conclusions:
- Propionibacterium species are an uncommon but significant cause of infection in pediatric patients.
- Foreign bodies, immunodeficiency, and malignancy are key predisposing factors.
- Prompt antimicrobial therapy and surgical intervention improve outcomes, though mortality can occur.