Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methodologic dependence of electroretinogram oscillatory potential amplitudes

M L Severns1, M A Johnson, G H Bresnick

  • 1Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased incidence of peripheral neuropathy with co-administration of stavudine and isoniazid in HIV-infected individuals.

AIDS (London, England)·2000
Same author

DNA sequence of the fowl adenovirus serotype 10 short fiber gene.

DNA sequence : the journal of DNA sequencing and mapping·2000
Same author

Delivery of avian cytokines by adenovirus vectors.

Developmental and comparative immunology·2000
Same author

Protection of pigs against classical swine fever with DNA-delivered gp55.

Vaccine·2000
Same author

A screening approach to the surveillance of patients with diabetes for the presence of vision-threatening retinopathy.

Ophthalmology·2000
Same author

Chronic recording of regenerating VIIIth nerve axons with a sieve electrode.

Journal of neurophysiology·2000

The International Society for Clinical Electrophysiology of Vision (ISCEV) protocol can predict diabetic retinopathy progression. Oscillatory potential amplitudes measured by the ISCEV method correlate well with other protocols, suggesting its utility.

Area of Science:

  • Ophthalmology
  • Clinical Electrophysiology
  • Diabetic Retinopathy Research

Background:

  • Diabetic retinopathy progression prediction is crucial for patient outcomes.
  • Current oscillatory potential (OP) protocols for predicting diabetic retinopathy differ from the International Society for Clinical Electrophysiology of Vision (ISCEV) standard.
  • The ISCEV protocol uses lower flash intensity and different preconditioning stimuli.

Purpose of the Study:

  • To evaluate the utility of the ISCEV electroretinogram (ERG) protocol for predicting diabetic retinopathy progression.
  • To compare summed oscillatory potential amplitudes measured by the ISCEV protocol versus a higher-intensity flash protocol.

Main Methods:

  • Measured summed oscillatory potential amplitudes in diabetic patients using both the ISCEV protocol and a higher-intensity flash protocol.

Related Experiment Videos

  • Assessed the correlation between OP amplitudes obtained from the two protocols.
  • Investigated the impact of different signal processing filters and measurement methods (caliper-square vs. summed peak-to-trough) on OP amplitude.

    • Main Results:

    • Summed oscillatory potential amplitudes measured by the ISCEV protocol were smaller but highly correlated with those from the higher-intensity flash protocol.
    • Different signal processing filters had a small but significant effect on summed OP amplitude.
    • Measurement methods (caliper-square or summed peak-to-trough) had an insignificant effect on measured OP amplitude.

    Conclusions:

    • The ISCEV protocol's summed oscillatory potential amplitudes are a reliable indicator for predicting diabetic retinopathy progression.
    • The ISCEV protocol offers a viable alternative for assessing diabetic retinopathy risk due to its correlation with established methods.