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Induction of oxygen free radical generation in human monocytes by lipoprotein(a)
P Riis Hansen1, A Kharazmi, M Jauhiainen
1Department of Medicine B, Rigshospitalet, University of Copenhagen, Denmark.
European Journal of Clinical Investigation
|July 1, 1994
Abstract:
The mechanism behind the association of elevated plasma lipoprotein(a) [Lp(a)] levels with atherosclerotic disease is unknown. In the present study, Lp(a) induced generation of oxygen free radicals by monocytes from selected healthy individuals in vitro. This observation may provide a link between Lp(a) and generation of oxidized LDL, which can promote multiple atherogenic cellular responses.