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Recombinant Salmonella vectors in vaccine development
Developments in Biological Standardization
|January 1, 1994
Summary
Genetically engineered avirulent Salmonella can be used as oral vaccines in animals and humans. These safe and effective recombinant vaccines provide stable antigen expression for robust immune responses.
Area of Science:
- Microbiology
- Immunology
- Vaccine Development
Background:
- Salmonella attenuation offers various methods for oral immunization.
- Oral vaccines can induce mucosal, humoral, and cellular immunity.
Purpose of the Study:
- To explore the use of genetically engineered avirulent Salmonella for oral vaccination.
- To assess the efficacy and safety of recombinant Salmonella vaccines.
Main Methods:
- Genetic engineering of avirulent Salmonella to express foreign antigens.
- Oral immunization of animals and humans with recombinant Salmonella.
Main Results:
- Recombinant avirulent Salmonella demonstrated stable, high-level expression of foreign antigens.
- Oral vaccination elicited significant immune responses.
Conclusions:
- Genetically engineered Salmonella are safe and efficacious oral vaccines.
- These vaccines are easy to administer and cost-effective.