Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans
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Summary
This summary is machine-generated.Secretin and cholecystokinin regulate pancreatic secretion in humans through negative feedback. This study investigated their roles in controlling bicarbonate and enzyme release.
Area Of Science
- Gastroenterology
- Endocrinology
- Physiology
Background
- Secretin's role in pancreatic feedback regulation is established in animals but less understood in humans.
- This study aimed to elucidate the feedback mechanisms of pancreatic secretion in human volunteers.
Purpose Of The Study
- To investigate the roles of secretin, cholecystokinin, neurotensin, and pancreatic polypeptide in the feedback regulation of human pancreatic secretion.
- To determine the specific hormones mediating this feedback loop.
Main Methods
- A specialized 5-lumen tube was used to collect gastric and duodenal contents separately in 10 fasting human volunteers.
- Acidified amino acid solutions were infused into the jejunum, alternated with control or trypsin solutions, to stimulate or inhibit pancreatic secretion.
- Plasma hormone levels and pancreatic outputs were measured throughout the study.
Main Results
- Infusion of control solutions increased bicarbonate and chymotrypsin outputs and all measured plasma hormones.
- Trypsin infusion significantly inhibited both bicarbonate and chymotrypsin outputs.
- This inhibition correlated with a significant decrease in plasma secretin and cholecystokinin levels, but not neurotensin or pancreatic polypeptide.
Conclusions
- Negative-feedback regulation of human pancreatic secretion of bicarbonate and enzymes is confirmed.
- This regulation is mediated by both secretin and cholecystokinin.