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Related Experiment Videos

Miconazole as inflammatory agent--I. Cellular and pathophysiological effects

S Hanada1, J A Sertié, E Waisbich

  • 1Department of Pharmacology, Universidade de São Paulo, Brazil.

General Pharmacology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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Miconazole injection in rats causes prolonged inflammation and swelling. This miconazole-induced paw edema, which is more intense than econazole

Area of Science:

  • Pharmacology
  • Inflammation Research
  • Drug Discovery

Background:

  • The development of reliable models for studying inflammation is crucial for drug discovery.
  • Antifungal agents can sometimes elicit inflammatory responses.
  • Understanding the mechanisms of drug-induced inflammation aids in predicting side effects.

Purpose of the Study:

  • To characterize the inflammatory response induced by subcutaneous miconazole injection in the rat paw.
  • To evaluate the potential of miconazole-induced paw edema as a model for screening anti-inflammatory agents.

Main Methods:

  • Subcutaneous injection of miconazole into the rat paw.
  • Observation and measurement of induced edema and inflammation.
  • Assessment of the effects of known anti-inflammatory drugs (chlorpheniramine, dexamethasone, phenylbutazone) on the edema.

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Main Results:

  • Subcutaneous miconazole injection reliably induced acute, localized, and sustained inflammation in the rat paw.
  • The miconazole-induced edema exhibited two distinct phases of rapid swelling.
  • The edema was significantly more intense (1.5-2 times) compared to that induced by econazole.
  • The development of miconazole edema was effectively inhibited by chlorpheniramine, dexamethasone, and phenylbutazone.

Conclusions:

  • Miconazole-induced paw edema serves as a robust and reproducible model of acute inflammation.
  • This model demonstrates sensitivity to established anti-inflammatory drugs.
  • The miconazole paw edema model shows promise for the screening and evaluation of novel anti-inflammatory drugs.