Miconazole as inflammatory agent--I. Cellular and pathophysiological effects
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S Hanada1, J A Sertié, E Waisbich
1Department of Pharmacology, Universidade de São Paulo, Brazil.
General Pharmacology
|July 1, 1994
Abstract:
1. Subcutaneous injection of miconazole into the rat paw evoked an acute, circumscribed and long-lasting inflammation. 2. Miconazole edema presented two defined phases of rapid swelling. 3. Miconazole edema was antagonized by chlorpheniramine, dexamethasone and phenylbutazone. 4. This edema was 1.5-2 times more intense than edema due to econazole. 5. It is suggested that miconazole paw edema might be useful in the process of screening anti-inflammatory drugs.