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The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse
V Arranz1, M Kress, M Ernoult-Lange
1Laboratoire d'Oncologie Moléculaire, Villejuif, France.
Gene
|November 18, 1994
Abstract:
The mouse gene MOK-2 encodes a protein with seven highly similar zinc fingers. The MOK-2 transcripts are preferentially detected in transformed cell lines, brain and testis tissues. The characterized 5'-flanking sequence differs from those of tissue-specific genes previously described. DNA sequence analysis shows that the promoter region lacks TATA and CCAAT boxes. Two short interspersed mouse genomic repeats (B2 sequences) found in this region exert a negative cis-acting effect on MOK-2 promoter activity.