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Ascorbic acid delays the development of tolerance to amphetamine induced anorexia but does not affect the reverse
B Gitanjali1, G Sivagnanam, R Raveendran
1Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
Indian Journal of Experimental Biology
|August 1, 1994
Abstract:
Ascorbic acid (1 g/kg) accentuated anorectic and locomotor effects of amphetamine (5 mg/kg) and delayed development of tolerance to anorectic effect. On the contrary, it did not alter the pattern of reverse tolerance to increased locomotor activity. The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.