Biochemical evaluation of acetyl salicylic acid in relation to different diets

Effect of aspirin on some biochemical and nutritional parameters was studied in rats fed with high fat, low fat, high protein or low protein diets. Two doses of aspirin (50 and 150 mg/kg rat body weight) were tested. The experiment continued for 10 days. Results showed that, when rats fed high fat diet, high dose of aspirin significantly decreased body weight gain, food efficiency ratio, plasma high density lipoproteins-cholesterol and its ratio to total cholesterol. Low dose of aspirin significantly reduced plasma total lipids. Low aspirin dose significantly increased plasma glucose level, when low fat diet was fed. Feeding high protein diet during administration of both doses of aspirin significantly reduced plasma total lipids and albumin/globulin ratio, while both doses significantly elevated plasma globulins. Low aspirin dose reduced plasma HDL-ch and significantly elevated plasma total proteins. In rats fed low protein diet, both aspirin doses significantly increased plasma triglycerides. The high dose significantly increased albumin/globulin ratio.