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Related Experiment Videos

Clinical hyperthermia with a new device: the current sheet applicator

B R Leigh1, B Stea, J R Cassady

  • 1Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson 85724.

International Journal of Radiation Oncology, Biology, Physics
|November 15, 1994
PubMed
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The novel current sheet applicator (CSA) effectively heats superficial tumors to therapeutic temperatures. Combined with radiotherapy, this microwave hyperthermia device shows excellent response rates and minimal toxicity for cancer treatment.

Area of Science:

  • Oncology
  • Medical Physics
  • Biomedical Engineering

Background:

  • Microwave hyperthermia offers a promising adjunct to radiotherapy for cancer treatment.
  • Existing microwave applicators have limitations in size and heating area efficiency.
  • The current sheet applicator (CSA) presents a novel design with improved physical characteristics for targeted heating.

Purpose of the Study:

  • To evaluate the clinical efficacy of the current sheet applicator (CSA) for heating superficial malignant tumors.
  • To assess the feasibility of using CSA in arrays for larger surface areas.
  • To determine the therapeutic potential of CSA in combination with radiotherapy.

Main Methods:

  • Nineteen patients with superficial malignant tumors received hyperthermia using one to four CSAs.

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  • Treatments aimed to reach a minimum tumor temperature of 42.5°C for 30 or 60 minutes.
  • Intratumoral temperatures were monitored using fiberoptic thermometry probes.
  • Concurrent fractionated radiation therapy was administered to all patients.

    • Main Results:

    • Mean tumor temperatures achieved were above therapeutic thresholds (average 42.2°C).
    • An overall response rate of 96% was observed across all assessable fields.
    • Tumor progression was minimal, with only three cases progressing during a median 6-month follow-up.
    • Treatment-related side effects were generally mild and self-limiting.

    Conclusions:

    • The current sheet applicator (CSA) is a viable new microwave hyperthermia device for superficial tumors.
    • CSA effectively heats tumors to therapeutic temperatures, demonstrating clinical efficacy.
    • Combining CSA with radiotherapy yields excellent response rates and acceptable toxicity profiles.