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Systemic candidiasis in four foals

L K Reilly1, J E Palmer

  • 1New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348.

Journal of the American Veterinary Medical Association
|August 1, 1994
PubMed
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Neonatal foals with birth hypoxia and sepsis developed systemic candidiasis. Antifungal treatment with amphotericin B and fluconazole proved effective in 3 of 4 foals, leading to successful recovery.

Area of Science:

  • Veterinary Neonatology
  • Equine Critical Care
  • Mycology in Animals

Background:

  • Neonatal foals admitted to intensive care often suffer from birth hypoxia and sepsis.
  • These conditions necessitate prolonged hospitalization and broad-spectrum antimicrobial therapy.
  • Invasive procedures are common in managing critically ill neonatal foals.

Observation:

  • Four foals experienced birth hypoxia-related issues and sepsis, requiring extended intensive care.
  • All foals developed infections of unknown origin during hospitalization.
  • Systemic candidiasis, caused by Candida albicans, was diagnosed in all four foals.

Findings:

  • Candida albicans was isolated from internal sites in all affected foals.
  • Three foals treated with intravenous amphotericin B and/or oral fluconazole showed positive clinical responses.

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  • Successful discharge was achieved for the three foals receiving antifungal therapy.

    • Implications:

    • Systemic candidiasis is a significant risk in neonatal foals with severe birth complications and prolonged antimicrobial use.
    • Antifungal therapy, including amphotericin B and fluconazole, can be effective in treating systemic candidiasis in foals.
    • Early diagnosis and targeted antifungal treatment are crucial for improving outcomes in critically ill neonatal foals.