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Ivermectin toxicosis in a kitten

D T Lewis1, S R Merchant, T M Neer

  • 1Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge 70803-8410.

Journal of the American Veterinary Medical Association
|August 15, 1994
PubMed
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Ivermectin overdose in a kitten caused severe neurological symptoms, including ataxia and tremors, leading to a fatal outcome. This highlights the critical need for caution when administering parenteral ivermectin to young cats.

Area of Science:

  • Veterinary Pharmacology
  • Toxicology
  • Feline Medicine

Background:

  • Ivermectin is a common antiparasitic drug used in veterinary medicine.
  • Ear mite infestations are prevalent in kittens and often treated with antiparasitics.
  • Parenteral administration involves injection, bypassing normal metabolic pathways.

Observation:

  • A 4-month-old kitten received subcutaneous ivermectin at 0.3 mg/kg for ear mites.
  • The kitten exhibited generalized ataxia, tremors, weakness, incoordination, and miosis.
  • Neurological deterioration progressed to coma within 12 hours.

Findings:

  • The kitten experienced severe adverse effects following ivermectin administration.
  • Despite supportive care, the kitten died seven days post-treatment.

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  • The observed toxicity suggests a narrow safety margin for ivermectin in kittens.

    • Implications:

    • Extreme caution is advised when using parenteral ivermectin in kittens.
    • Dosage and administration routes for ivermectin in felines require careful consideration.
    • Further research into ivermectin safety and efficacy in juvenile cats is warranted.