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Related Experiment Videos

Lactoferricin, a new antimicrobial peptide

E M Jones1, A Smart, G Bloomberg

  • 1Department of Microbiology, Bristol Royal Infirmary, UK.

The Journal of Applied Bacteriology
|August 1, 1994
PubMed
Summary

Lactoferricin B (LF-B) shows broad-spectrum antimicrobial activity against bacteria and Candida albicans. However, its effectiveness is limited in conditions mimicking the body, suggesting a transient role at mucosal surfaces.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Antimicrobial Peptides

Background:

  • Lactoferricin B (LF-B) is a peptide derived from bovine lactoferrin.
  • LF-B exhibits antimicrobial properties.

Purpose of the Study:

  • To determine the antimicrobial spectrum of LF-B.
  • To assess the potential in vivo applications of LF-B.

Main Methods:

  • Determined minimum inhibitory and microbicidal concentrations of LF-B.
  • Tested against various bacterial species and Candida albicans.
  • Evaluated effects of growth phase, inoculum size, pH, and ionic strength.

Main Results:

  • LF-B was bactericidal against a wide range of bacteria and Candida albicans.
  • Proteus spp., Pseudomonas cepacia, and Serratia spp. were resistant.
  • Activity was inhibited by increased ionic strength, inoculum size, and acidic pH.
  • Inhibition observed with 5% cow's milk and mucin.

Conclusions:

  • LF-B can reduce microbial numbers in simple media.
  • Sensitivity to physical variables raises doubts about in vivo efficacy.
  • LF-B may exert a transient antimicrobial effect on mucosal surfaces.

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