Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary capillary transport function from flow-limited indicators

S H Audi1, G S Krenz, J H Linehan

  • 1Biomedical Engineering Department, Marquette University, Milwaukee 53233.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs after Exposure to Hyperoxia.

IEEE journal of translational engineering in health and medicine·2014
Same author

An exploration of spatial risk assessment for soil protection: estimating risk and establishing priority areas for soil protection.

The Science of the total environment·2014
Same author

BioInnovate Ireland--fostering entrepreneurial activity through medical device innovation training.

Annals of biomedical engineering·2013
Same author

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma.

Journal of lipid research·2010
Same author

Is overspecialization a threat?

Wisconsin medical journal·2010
Same author

Lung tissue mitochondrial benzodiazepine receptors increase in a model of pulmonary inflammation.

Lung·2002
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

This study introduces a novel method using flow-limited indicators to estimate pulmonary capillary blood volume and transit times. The technique accurately measures lung microcirculation parameters in dog lung lobes.

Area of Science:

  • Physiology
  • Pharmacokinetics
  • Medical Imaging

Background:

  • Accurate estimation of pulmonary capillary blood volume and transit time distribution is crucial for understanding lung function and disease.
  • Traditional methods may have limitations in precisely quantifying these microcirculatory parameters.

Purpose of the Study:

  • To evaluate the efficacy of rapidly diffusing (flow-limited) indicators for estimating pulmonary capillary blood volume and capillary transit time distribution.
  • To develop and validate theoretical equations relating indicator transit times to microcirculatory parameters.
  • To apply this method to experimental data from isolated dog lung lobes.

Main Methods:

  • Development of theoretical equations linking moments of venous concentration-time curves for vascular reference and flow-limited diffusible indicators to capillary transport function moments.

Related Experiment Videos

  • Utilized a least-squares optimization procedure to estimate moments of the capillary transport function.
  • Applied the method to isolated dog lung lobes using [14C]-diazepam as the diffusible indicator, adjusting its partition coefficient via perfusate albumin concentration.

    • Main Results:

    • The study derived equations relating indicator moments to capillary transport function moments, enabling estimation of capillary volume and transit time distribution.
    • Application to dog lung lobes yielded an estimated capillary volume of approximately 48% of total lobar volume.
    • The mean transit time and relative dispersion of the capillary transport function were also quantified.

    Conclusions:

    • Rapidly diffusing indicators, when used with appropriate theoretical models and optimization techniques, provide a viable method for estimating pulmonary capillary blood volume and transit time distribution.
    • The developed approach offers a non-invasive way to assess lung microcirculatory dynamics.
    • This method has potential applications in both research and clinical settings for evaluating pulmonary health.