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Related Experiment Videos

Colorectal tumours and pit pattern

S Kudo1, S Hirota, T Nakajima

  • 1Department of Gastroenterology, Akita Red Cross Hospital, Japan.

Journal of Clinical Pathology
|October 1, 1994
PubMed
Summary

Colorectal pit patterns observed during colonoscopy correlate with underlying crypt structures and cell histology. These pit patterns can indicate lesion type and depth of invasion, aiding in cancer diagnosis.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Histopathology

Background:

  • Endoscopic visualization of colorectal surface pits offers insights into underlying mucosal structures.
  • Understanding the correlation between pit morphology and crypt architecture is crucial for diagnosing colorectal lesions.

Purpose of the Study:

  • To investigate the morphological and histopathological associations between surface pits observed via colonoscopy and crypt structures in histological sections.
  • To examine these associations within the context of colorectal tumors.

Main Methods:

  • Analysis of 14,023 colonoscopy cases with in vivo and in vitro pit observations using magnifying endoscopy and stereo microscopy.
  • Histological examination of pit patterns in 100 glands using light microscopy.

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Main Results:

  • Seven pit patterns were identified: normal round, small round, small asteroid, large asteroid, oval, gyrus-like, and non-pit.
  • Significant correlations were found between pit patterns, underlying crypt/gland structure, and cellular histology.
  • Specific pit patterns (types 3-6) were associated with protruding lesions, while type 2 was linked to depressed lesions; depressed lesions showed faster invasion.

Conclusions:

  • A direct association exists between observed pits and underlying crypts.
  • Malignant transformation of adenoma glands leads to branching carcinoma glands, while normal glands becoming malignant result in straight carcinoma glands.
  • The small round pit pattern may indicate a transition from normal to straight carcinoma glands.