Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Immunopathogenesis of toxoplasmic encephalitis

C A Hunter¹, J S Remington

¹Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301.

The Journal of Infectious Diseases

|November 1, 1994

Summary

Toxoplasmic encephalitis (TE) is rising in immunocompromised patients due to latent Toxoplasma gondii reactivation. Understanding the brain's immune response is crucial for managing this infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Solvation and surface effects on polymorph stabilities at the nanoscale.

Chemical science·2017

Same author

Immunity to Toxoplasma gondii--into the 21st century.

Parasite immunology·2015

Same author

Parasite dissemination and the pathogenesis of toxoplasmosis.

European journal of microbiology & immunology·2014

Same author

Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.

Schizophrenia research·2013

Same author

A comparison of various egg media for the routine isolation of Mycobacterium tuberculosis.

Journal of bacteriology·2010

Same author

An epidemic of diarrhea in the newborn nursery caused by a milk-borne epidemic in the community.

The Journal of pediatrics·2010

Area of Science:

Neuroimmunology
Infectious Diseases
Immunology

Background:

Toxoplasmic encephalitis (TE) incidence correlates with rising immunodeficiency cases.
Reactivation of latent Toxoplasma gondii infection is a key concern in immunocompromised individuals.
The brain's unique immune environment necessitates understanding systemic responses to Toxoplasma gondii.

Purpose of the Study:

To elucidate the immune mechanisms underlying latent Toxoplasma gondii infection in the brain.
To investigate the role of systemic immunity in controlling Toxoplasma gondii within the central nervous system.
To explore the cellular interactions mediating brain immunity during Toxoplasma gondii infection.

Main Methods:

Utilized murine models to study the immune response to Toxoplasma gondii.
Investigated the roles of specific cytokines, Natural Killer (NK) cells, and T cells.
Examined the interactions between glial cells (microglia, astrocytes) and T cells in the brain.

Main Results:

Identified critical roles for cytokines, NK cells, and T cells in protective immunity against Toxoplasma gondii.
Highlighted the importance of glial cell and T cell interactions in brain immunity.
Provided insights into the regulation of latent Toxoplasma infection.

Conclusions:

The immune system, particularly T cells and cytokines, is vital for maintaining latent Toxoplasma gondii infection.
Glial cells and infiltrating T cells collaborate to establish brain immunity against Toxoplasma gondii.
Further research into these neuro-immune interactions is essential for understanding and treating TE.

Related Experiment Videos