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Class I major histocompatibility complex-restricted cytotoxic T lymphocytes are not necessary for heterotypic

B S Bender1, W E Bell, S Taylor

  • 1Geriatric Research, Education, and Clinical Center, VA Medical Center, Gainesville, FL 32608-1197.

The Journal of Infectious Diseases
|November 1, 1994
PubMed

Mice transgenic for beta 2-microglobulin deletion (beta 2M-/-) were immunized intranasally with either a recombinant vaccinia virus that expressed both nucleoprotein and interleukin-2 or by infection with H3N2 influenza virus; 3-4 weeks later they were challenged with H1N1 influenza virus. The immunized beta 2M-/- mice had increased survival and enhanced clearance of virus relative to nonimmune controls. This protection correlated with the development of class II major histocompatibility complex-restricted pulmonary cytotoxic T lymphocyte activity and nasal IgA anti-nucleoprotein antibody. Heterotypic immunity can therefore be generated by a mechanism that does not involve class I major histocompatibility complex-restricted T cells.

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