Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium magnesium phosphate granules: atomistic simulations explaining cell death

K Simkiss1, M G Taylor

  • 1Department of Pure and Applied Zoology, University of Reading, UK.

The Journal of Experimental Biology
|May 1, 1994
PubMed
Summary

Invertebrates utilize intracellular granules of calcium magnesium phosphates for ion storage and metal detoxification. Computational simulations reveal how ion substitutions impact these granules and cellular functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transfusion in critical care - a UK regional audit of current practice.

Anaesthesia·2017
Same author

Analysis of DNA size, content and cell cycle in leaves of Napier grass (Pennisetum purpureum Schum.).

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Histology of, and physical factors affecting, transient GUS expression in pearl millet (Pennisetum glaucum (L.) R. Br.) embryos following microprojectile bombardment.

Plant cell reports·2013
Same author

Enhanced GUS gene expression in cereal/grass cell suspensions and immature embryos using the maize uhiquitin-based plasmid pAHC25.

Plant cell reports·2013
Same author

A CANADIAN HEALTH PROGRAM WHAT ARE THE ISSUES?

Canadian Medical Association journal·2010
Same author

Broadband behavior of an optical-digital focus-invariant system.

Optics letters·2009

Area of Science:

  • Biomineralization
  • Cellular Physiology
  • Computational Chemistry

Background:

  • Many invertebrates possess intracellular granules composed of amorphous calcium magnesium phosphates.
  • These granules are hypothesized to function as critical ion reservoirs and sites for heavy metal detoxification within cells.

Purpose of the Study:

  • To investigate the fundamental properties of calcium magnesium phosphate granules in invertebrates.
  • To elucidate the impact of ion substitutions on the structural stability and energetic properties of these granules.
  • To understand the physiological consequences of altered granule composition.

Main Methods:

  • Calculation of interatomic potentials and force constants for relevant ions.
  • Utilizing computer simulations to model invertebrate crystal lattices.

Related Experiment Videos

  • Analyzing the effects of ion substitutions on lattice energies.

    • Main Results:

    • Interatomic potentials and force constants for ions within the granules were successfully computed.
    • Computer simulations demonstrated how ion substitutions influence the energy of crystal lattices.
    • The study provides quantitative data on the structural and energetic characteristics of these biomineral granules.

    Conclusions:

    • The findings offer significant insights into the mechanisms governing the formation of intracellular granules.
    • Understanding the effects of ion substitutions is crucial for comprehending cellular physiology in invertebrates.
    • This research lays the groundwork for future studies on biomineralization and cellular ion regulation.