Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two steroidal alkaloids from a sponge, Corticium sp

J Jurek1, P J Scheuer

  • 1Department of Chemistry, University of Hawaii at Manoa, Honolulu.

Journal of Natural Products
|July 1, 1994
PubMed
Summary

Two new steroidal alkaloids, Lokysterolamine A and B, were discovered in an Indonesian sponge. These compounds represent novel chemical structures from the Corticium genus.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structures and possible functions of epoxypukalide and pukalide : Diterpenes associated with eggs of sinularian soft corals (Cnidaria, Anthozoa, Octocorallia, Alcyonacea, Alcyoniidae).

Journal of chemical ecology·2013
Same author

Course of Chronic Active Hepatitis in Wilson's Disease [Abstract].

Proceedings of the Royal Society of Medicine·2010
Same author

A Controlled Trial of D-penicillamine Therapy in Primary Biliary Cirrhosis [Abstract].

Proceedings of the Royal Society of Medicine·2010
Same author

Natural history of hepatitis B in perinatally infected carriers.

Archives of disease in childhood. Fetal and neonatal edition·2004
Same author

Progress in the clinical development of new marine-derived anticancer compounds.

Anti-cancer drugs·2004
Same author

Chemical defenses of the sacoglossan mollusk Elysia rufescens and its host Alga bryopsis sp.

Journal of chemical ecology·2002

Area of Science:

  • Marine Natural Products Chemistry
  • Marine Biology
  • Pharmacognosy

Background:

  • Marine sponges are a rich source of structurally diverse bioactive compounds.
  • The genus Corticium is an underexplored source of novel marine natural products.

Purpose of the Study:

  • To isolate and characterize new steroidal alkaloids from a marine sponge.
  • To determine the chemical structures of Lokysterolamine A and B.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation using spectroscopic methods (e.g., NMR, MS).

Main Results:

  • Two novel steroidal alkaloids, Lokysterolamine A and B, were identified.
  • Lokysterolamine A is N,N-dimethyl- and Lokysterolamine B is N-acetyl-4 beta-hydroxy-3-epi-plakinamine A.

Conclusions:

  • The study expands the known chemical diversity of steroidal alkaloids.
  • The discovery highlights the potential of Indonesian marine sponges as a source of novel compounds.

Related Experiment Videos