Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MN20, a D2 cyclin found in brain, is implicated in neural differentiation

M E Ross1, M Risken

  • 1Department of Neurology, University of Minnesota, Minneapolis 55455.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 1, 1994
PubMed
Summary

This study identifies a brain-specific cyclin D2 (MN20) gene. Its expression in neuronal precursors suggests roles in brain development beyond cell cycle regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urologic care and progression to end-stage kidney disease: a Chronic Kidney Disease in Children (CKiD) nested case-control study.

Journal of pediatric urology·2019
Same author

Lymphogranuloma in the female.

The Punjab medical journal·2010
Same author

Gynecological Urology.

Journal of the National Medical Association·2010
Same author

Granuloma of the Cervix.

Journal of the National Medical Association·2010
Same author

The Initial Lesion of Granuloma Inguinale: Report of a Case.

Journal of the National Medical Association·2010
Same author

An Unusual Bladder Injury.

Journal of the National Medical Association·2010

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Cyclins regulate cell division progression.
  • D-type cyclins are key in the G1 to S phase transition.
  • They are typically found in actively dividing tissues.

Purpose of the Study:

  • To isolate and characterize novel cyclin gene forms.
  • To investigate the expression pattern of a specific cyclin D2 message (MN20).
  • To explore the function of cyclin D2 in neuronal development.

Main Methods:

  • cDNA cloning to isolate MN20.
  • Analysis of gene expression patterns in the brain.

Main Results:

  • A cyclin D2 cDNA clone, MN20, was isolated.

Related Experiment Videos

  • MN20 expression is restricted to specific neuronal precursor populations in the brain.
  • Expression observed in cerebellar granule neuroblasts and embryonic cerebral cortex precursors.
  • Notably, expression occurs in both dividing and postmitotic neuronal precursors.

    • Conclusions:

    • The cyclin D2 gene (MN20) has region-specific functions in neuronal differentiation.
    • These functions may extend beyond cell cycle promotion.
    • Cyclin D2 appears to play a role at the transition between mitosis and neuronal maturation.