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Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies
L R Rogers1, M A Weinstein, M L Estes
1Department of Neurology, Cleveland Clinic Foundation, Ohio.
Journal of Neurosurgery
|December 1, 1994
Summary
Diffuse cerebral astrocytomas can present atypically on brain imaging, mimicking other neurological conditions. This can delay diagnosis, highlighting the need for careful interpretation of computerized tomography (CT) and magnetic resonance (MR) scans.
Area of Science:
- Neuro-oncology
- Neuroradiology
- Neuropathology
Background:
- Cerebral astrocytomas are primary brain tumors.
- Imaging characteristics can vary, posing diagnostic challenges.
Purpose of the Study:
- To describe the clinical and imaging features of diffuse cerebral astrocytomas.
- To highlight potential misinterpretations of neuroimaging findings.
Main Methods:
- Retrospective analysis of eight patients with cerebral astrocytomas.
- Review of computerized tomography (CT) and magnetic resonance (MR) imaging.
- Histopathological correlation.
Main Results:
- Diffuse bilateral cerebral hemisphere abnormalities were noted on CT/MR imaging.
- In five patients, tumors were not suspected, with findings mistaken for other conditions.
- Progression of abnormal densities and development of enhancing masses were observed over time.
Conclusions:
- Neuroimaging findings in diffuse cerebral astrocytoma can be atypical and mimic other diseases.
- Misdiagnosis is possible, especially when conditions affect cerebral hemisphere white matter.
- Awareness of these atypical presentations is crucial for accurate diagnosis.