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Inflammatory meningioma of the fourth ventricle. Case report
M Ferrara1, L Bizzozero, G D'Aliberti
1Department of Neurosurgery, Niguarda Ca' Granda Hospital, Milan, Italy.
Abstract:
A case of meningioma with inflammatory reaction within the fourth ventricle in a 37 year-old man is described. The differential diagnosis between inflammatory meningioma, plasma cell granuloma and a possible collision of a meningioma with a plasmacytoma is discussed. The immunohistochemical examination of plasma cell population is emphasized. This is the first case reported of inflammatory meningioma located in the fourth ventricle.
Insights
This study describes the first reported case of inflammatory meningioma in the fourth ventricle. Immunohistochemistry was crucial for diagnosing this rare brain tumor and differentiating it from other plasma cell-rich lesions.
Area of Science:
- Neuropathology
- Neuro-oncology
- Surgical Pathology
Background:
- Meningiomas are common primary brain tumors, typically benign.
- Inflammatory reactions within meningiomas are rare, posing diagnostic challenges.
- The fourth ventricle is an unusual location for meningioma, especially with inflammatory features.
Observation:
- A case of a 37-year-old male with a fourth ventricular mass is presented.
- The tumor exhibited significant inflammatory cell infiltration, predominantly plasma cells.
- Histopathological and immunohistochemical analyses were performed.
Findings:
- The diagnosis of inflammatory meningioma was established.
- Differential diagnoses considered included plasma cell granuloma and collision tumors.
- Immunohistochemistry was key to characterizing the plasma cell population and confirming the diagnosis.
Implications:
- This case highlights the importance of considering inflammatory meningioma in the differential diagnosis of fourth ventricular tumors.
- The findings underscore the utility of immunohistochemistry in distinguishing inflammatory meningioma from other plasma cell-rich lesions.
- This report represents the first documented instance of inflammatory meningioma occurring within the fourth ventricle, expanding the known spectrum of meningioma presentations.