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Enteral formula composition does not affect response to lethal infectious challenge in mice

J D Alder1, J Meulbroek, K Jarvis

  • 1Abbott Laboratories, Anti-infective Research Division, Abbott Park, IL 60064-3500.

The Journal of Nutrition
|November 1, 1994
PubMed
Summary

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Specialized enteral formulas did not improve survival or cure rates in mice challenged with Listeria, influenza, or Candida infections. These animal models may not effectively differentiate the effects of modified nutrient compositions in enteral formulas.

Area of Science:

  • Immunology
  • Nutrition Science
  • Microbiology

Background:

  • Enteral formulations are used to provide nutrition, and some contain specialized ingredients purported to enhance immune response.
  • Previous studies suggested certain enteral formulas, like Impact, could improve resistance to infectious challenges.

Purpose of the Study:

  • To evaluate the efficacy of commercially available enteral formulas (Osmolite HN, Perative, Impact) in enhancing host resistance against infectious challenges.
  • To determine if modified nutrient compositions in enteral formulas impact survival and cure rates in animal models of infection.

Main Methods:

  • CF-1 outbred female mice were fed either a nonpurified diet or one of three liquid enteral formulas (Osmolite HN, Perative, Impact).
  • Mice were subsequently challenged with lethal doses of Listeria monocytogenes, influenza A, or Candida albicans.

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  • Survival rates, mean survival times, and cure rates in infected organs (spleen, lungs, kidneys) were assessed.

    • Main Results:

    • No significant differences in mean survival time or percentage of survivors were observed between mice fed liquid formulas and those on a nonpurified diet across all infection models.
    • Examination of infected organs revealed no differences in cure rates among the groups.
    • Contrary to prior research, the Impact formula did not enhance resistance to Listeria monocytogenes compared to Osmolite HN.

    Conclusions:

    • The tested enteral formulations (Osmolite HN, Perative, Impact) did not demonstrate improved efficacy in enhancing host resistance against acute lethal infections in mice.
    • Acute lethal animal models may have limitations in detecting subtle differences in the immunomodulatory effects of modified enteral formula compositions.