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Effect of Golytely on serum electrolytes and hydration status of infants

M C Donahue1, J K Evangelista, R C Shamberger

  • 1Department of Surgery, Children's Hospital, Boston, MA 02115.

Journal of Pediatric Surgery
|August 1, 1994
PubMed

Insights

Golytely (GLP), an oral bowel prep, showed minimal, clinically insignificant electrolyte shifts in infants and children undergoing intestinal surgery. The preparation is safe for pediatric use, maintaining hydration status effectively.

Area of Science:

  • Pediatric Gastroenterology
  • Surgical Preparation
  • Clinical Nutrition

Background:

  • Golytely (GLP) is a standard oral lavage solution for pediatric intestinal surgery.
  • Its nonabsorbable electrolyte composition aims to prevent dehydration and electrolyte imbalances.
  • Systematic evaluation of GLP's impact on infant hydration and electrolytes is lacking.

Purpose of the Study:

  • To assess the effects of Golytely (GLP) on hydration status and serum electrolytes in infants and children.
  • To determine the clinical significance of any observed electrolyte shifts.

Main Methods:

  • A cohort of 48 children (0-24 months) received GLP for intestinal surgery.
  • Serum electrolytes and blood urea nitrogen were measured pre- and post-administration.
  • Patients consumed clear fluids, including Rehydralyte, ad libitum; minimal IV fluids were used.

Main Results:

  • Statistically significant shifts in serum electrolytes were observed, including decreased potassium and chloride, and increased CO2.
  • These electrolyte changes were not clinically significant.
  • Hydration status was generally maintained with unrestricted clear fluid intake.

Conclusions:

  • Golytely (GLP) administration results in statistically, but not clinically, significant electrolyte shifts in pediatric patients.
  • The preparation appears safe for use in infants and children undergoing intestinal surgery, with adequate hydration maintained.

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