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Updated: Jul 29, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
Published on: October 18, 2013
In vitro transdermal permeation of nifedipine from thickened microemulsions
1Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Italy.
Abstract:
The in vitro transdermal absorption of nifedipine from microemulsions was studied using the skin of the hairless mouse as membrane. Two microemulsions (N.1 and N.2) were prepared and thickened; they contained respectively 1.8% and 2.0% of nifedipine in solution. The fluxes of the drug from the microemulsions were 7.8 micrograms/h/cm2 from N.1 and 18.6 micrograms/h/cm2 from N.2. Two reference gels were prepared to examine whether the components of the microemulsion could behave as enhancer: their fluxes were very low, below 0.5 microgram/h/cm2. Nifedipine dissolved in microemulsion and protected from light showed no degradation for up to six months.
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