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Effect of interstitial cystitis on drug absorption from urinary bladder
X Gao1, C A Buffington, J L Au
1College of Pharmacy, Ohio State University, Columbus.
The Journal of Pharmacology and Experimental Therapeutics
|November 1, 1994
Summary
Feline interstitial cystitis (FIC) significantly increases bladder permeability to drugs like salicylate, leading to higher absorption and altered drug clearance. This suggests potential changes in drug dosing for cats with this condition.
Area of Science:
- Pharmacology
- Urology
- Veterinary Medicine
Background:
- Previous studies demonstrated in vivo drug absorption from the urinary bladder.
- Interstitial cystitis is a lower urinary tract disease potentially involving bladder inflammation.
Purpose of the Study:
- To investigate the impact of feline interstitial cystitis (FIC) on bladder drug permeability.
- To compare the bladder absorption of salicylate in healthy cats versus cats with FIC.
Main Methods:
- Administered sodium salicylate intravesically and [14C]salicylic acid intravenously to healthy and FIC cats.
- Determined systemic clearance and bioavailability of intravesical salicylate.
- Compared salicylate disposition (metabolism and elimination) in healthy and FIC cats.
Main Results:
- FIC cats exhibited significantly higher bladder permeability to salicylate (9% bioavailability) compared to healthy cats (1% bioavailability).
- The apparent bladder absorption rate constant and peak plasma concentrations were 7-8 times higher in FIC cats.
- Lower salicylate clearance in FIC cats was attributed to decreased metabolism and slower drug elimination.
Conclusions:
- Feline interstitial cystitis markedly enhances bladder permeability to salicylate.
- FIC alters salicylate disposition, involving both reduced metabolism and slower elimination.
- These findings have implications for drug therapy in cats with interstitial cystitis.