Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The antiphospholipid syndrome

G R Hughes1, M A Khamashta

  • 1Lupus Arthritis Research Unit, Rayne Institute, London.

Journal of the Royal College of Physicians of London
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minocycline-induced arthritis.

Clinical and experimental rheumatology·1998
Same author

Does SLE flare during pregnancy?

Scandinavian journal of rheumatology. Supplement·1998
Same author

Therapeutic advances in systemic lupus erythematosus.

Current opinion in rheumatology·1998
Same author

Arterial disease in lupus and secondary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodies but not with antibodies against oxidized low-density lipoprotein.

British journal of rheumatology·1998
Same author

Lack of cross-reaction between antibodies to beta2-glycoprotein-I and oxidized low-density lipoprotein in patients with antiphospholipid syndrome.

British journal of rheumatology·1998
Same author

Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes.

Arthritis and rheumatism·1998

Antiphospholipid syndrome (APS) involves blood clots and pregnancy loss, linked to antiphospholipid antibodies. Treatments targeting clotting events are more effective than those addressing the immune cause.

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy complications.
  • Initially termed anticardiolipin syndrome, it is associated with antiphospholipid antibodies.
  • APS affects various medical specialties, including neurology and cardiology.

Purpose of the Study:

  • To review the clinical features and pathogenetic role of antiphospholipid antibodies in APS.
  • To discuss the current understanding and future directions for APS research and treatment.

Main Methods:

  • Review of clinical observations and existing literature on antiphospholipid syndrome.
  • Discussion of the pathogenetic mechanisms and therapeutic strategies for APS.

Related Experiment Videos

Main Results:

  • Antiphospholipid antibodies play a pathogenic role in APS vasculopathy.
  • Treatments targeting thrombotic events show greater success than those targeting immunological abnormalities.
  • Animal models are crucial for developing targeted therapies.

Conclusions:

  • Antiphospholipid syndrome is a significant condition with complex mechanisms.
  • Further research, particularly using animal models, is needed to elucidate APS pathogenesis.
  • Current effective treatments focus on managing thrombotic complications.