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Hyperprolactinemia in Reiter's syndrome

L J Jara1, L H Silveira, M L Cuéllar

  • 1Department of Medicine, Louisiana State University School of Medicine in New Orleans.

The Journal of Rheumatology
|July 1, 1994
PubMed
Summary
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Elevated prolactin (PRL) levels were observed in 36% of patients with Reiter's syndrome (RS), a significantly higher rate than in other spondyloarthropathies. This suggests a potential role for PRL in RS pathogenesis and disease expression.

Area of Science:

  • Immunology
  • Endocrinology
  • Rheumatology

Background:

  • Certain immunoregulatory hormones, such as prolactin (PRL), are implicated in the development and manifestation of autoimmune diseases.
  • The specific role of PRL in spondyloarthropathies, including Reiter's syndrome (RS), requires further investigation.

Purpose of the Study:

  • To explore the potential involvement of PRL in the pathogenesis and disease expression of spondyloarthropathies.
  • To determine if PRL levels are associated with clinical manifestations in patients with RS.

Main Methods:

  • Serum PRL levels were measured using radioimmunoassay in patients with spondyloarthropathies (including RS), acute anterior uveitis (AAU), and healthy controls.
  • Clinical symptoms at the time of blood collection were correlated with measured PRL levels.

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Main Results:

  • Hyperprolactinemia (PRL > 20 ng/ml) was detected in 36% of RS patients, compared to only 2.9% in ankylosing spondylitis patients and none in psoriatic arthritis, AAU, or control groups (p < 0.001).
  • RS patients with hyperprolactinemia exhibited a higher frequency of conjunctivitis, urethritis, dysentery, and uveitis compared to normoprolactinemic RS patients.

Conclusions:

  • The findings indicate a potential role for the immunoregulatory hormone prolactin in the pathogenesis and disease expression of Reiter's syndrome.
  • Further research into the mechanisms linking PRL to RS is warranted.