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Capillary permeability in fibromyalgia

W Grassi1, P Core, G Carlino

  • 1Department of Rheumatology, University of Ancona, Italy.

The Journal of Rheumatology
|July 1, 1994
PubMed
Summary
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This study found reduced capillary permeability and tracer persistence in fibromyalgia (FMS) patients. These microvascular changes may be linked to low capillary flow or hypotension in FMS.

Area of Science:

  • Microcirculation research
  • Vascular biology
  • Fibromyalgia pathophysiology

Background:

  • Fibromyalgia (FMS) is a complex chronic pain disorder.
  • Microvascular dysfunction is increasingly implicated in FMS pathogenesis.

Purpose of the Study:

  • To investigate capillary permeability in patients with fibromyalgia.
  • To compare nailfold capillary function in FMS patients versus healthy controls.

Main Methods:

  • Dynamic fluorescence videomicroscopy and videodensitometric analysis were used.
  • Transcapillary diffusion of sodium fluorescein was assessed in nailfold capillaries.
  • Pericapillary and interstitial fluorescent light intensities (FLI) were measured.

Main Results:

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  • A trend towards increased early transcapillary diffusion was observed in FMS patients.
  • Significantly lower interstitial fluorescent light intensities (FLI) were found in FMS patients from 5 to 30 minutes.
  • Reduced interstitial tracer persistence was evident in FMS patients compared to controls.

Conclusions:

  • Transcapillary permeability and interstitial tracer persistence are significantly reduced in fibromyalgia.
  • Abnormal microvascular dynamics, potentially due to low capillary flow or hypotension, may underlie these findings in FMS.