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Glucose tolerance and ageing

R W Stout1

  • 1Department of Geriatric Medicine, Queen's University of Belfast, Northern Ireland, UK.

Journal of the Royal Society of Medicine
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

As people age, hyperglycemia and type 2 diabetes increase due to insulin resistance. Physical activity can help mitigate these age-related glucose metabolism changes.

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Area of Science:

  • Gerontology
  • Metabolic diseases
  • Endocrinology

Background:

  • Hyperglycemia, impaired glucose tolerance, and type 2 diabetes mellitus increase with age.
  • The primary mechanism involves postreceptor insulin resistance.
  • Other contributing factors include inadequate insulin secretion and reduced hepatic insulin sensitivity.

Purpose of the Study:

  • To explore the age-related changes in glucose metabolism.
  • To identify the underlying mechanisms of age-related insulin resistance.
  • To discuss factors influencing these metabolic alterations.

Main Methods:

  • Review of existing literature on aging and glucose metabolism.
  • Analysis of physiological changes related to insulin action.

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  • Identification of contributing and mitigating factors.

    • Main Results:

    • Insulin resistance at the postreceptor level is a key factor in age-related hyperglycemia.
    • Decreased insulin secretion and hepatic glucose output regulation also contribute.
    • Obesity, renal failure, and certain drugs can exacerbate these changes.

    Conclusions:

    • Age-related metabolic changes, including insulin resistance and impaired glucose tolerance, are significant.
    • Lifestyle factors like physical activity can positively influence glucose regulation in older adults.
    • Understanding these mechanisms is crucial for managing age-associated diabetes and metabolic disorders.